1.2. Pediatrics
With the exception of dantrolene, skeletal muscle relaxants are not FDA-approved for use in children [1-18]. Safety and efficacy of cyclobenzaprine extended-release capsules (Amrix) have not been evaluated in pediatric patients, including adolescents [1, 7, 8]. Select skeletal muscle relaxants are FDA-approved for use in adolescents. Recommended pediatric dosages and age limitations for skeletal muscle relaxants are summarized in Table 2.
Although not FDA-approved, baclofen has been used for spasticity in pediatric patients 2 to 7 years of age in doses up to 40 mg/day and in children 8 to 11 years of age in maximum doses of 60 mg/day [1].
| Drug Name | Treatment Indication | Maximum Recommended Dosage |
|---|---|---|
| baclofen | spasticity | Greater than or equal to 12 years of age: 80 mg/day, in divided doses |
| dantrolene | spasticity | Greater than or equal to 5 years of age: 400 mg/day, in divided doses |
| carisoprodol | muscle spasm | Greater than or equal to 16 years of age: 1400 mg/day, in divided doses |
| cyclobenzaprine tablets | muscle spasm | Greater than or equal to 15 years of age: 30 mg/day, in divided doses |
| metaxalone | muscle spasm | Greater than 12 years of age: 3200 mg/day, in divided doses |
| methocarbamol | muscle spasm | Greater than or equal to 16 years of age: 8 g/day, in divided doses |