Table 2: Recommended Adult Dosages for ACIs: Combination Therapy

Treatment Indication Drug Name Dosage Form and Strength Maximum Recommended Dosage
moderate to severe Alzheimer’s dementia in patients stabilized on donepezil alone or memantine and donepezil memantine extended-release/donepezil (Namzaric®) capsules (7 mg/10 mg, 14 mg/10 mg, 21 mg/10 mg, 28 mg/10 mg) 28 mg/10 mg once daily

Although not FDA-approved, ACIs have also been evaluated for use in vascular dementia, dementia with Lewy bodies, post stroke aphasia, and memory improvement in multiple sclerosis patients.