Table 15: Select non-SSRI Antidepressant Dosage Modifications in Renal Impairment – Other Miscellaneous Agents

Drug Name Dosage in Renal Impairment
Bupropion Administer cautiously in renal impairment due to potential for accumulation and risk for adverse events (e.g., seizures); consider reduced dosage/dosage frequency Forfivo™ XL: not recommended in renal impairment as no lower dose available
Trazodone Use cautiously in patients with CrCl less than 50 ml/min


  • CrCl = creatinine clearance