Table 2: Recommended Adult Hydrocodone Dosages: Combination Therapy
| Drug/Indication | Dosage Forms/Strengths | Usual Dosage Regimen | Maximum Recommended Dose |
|---|---|---|---|
| Analgesic hydrocodone bitartrate/ acetaminophen (Lortab®, Norco®, generics) | 5 mg/300 mg, 7.5 mg/300 mg, 10 mg/300 mg, 2.5 mg/325 mg, 5 mg/325 mg, 7.5 mg/325 mg, 10 mg/325 mg tablets; 7.5 mg/325 mg/15 ml or 10 mg/325 mg/15 ml solution; 10 mg/300 mg/15 ml elixir | 2.5-10 mg every 4-6 hours as needed | 60 mg/4000 mg daily* |
| Analgesic hydrocodone bitartrate/ ibuprofen (Vicoprofen®, Ibudone®, Reprexain®, generics) | 2.5 mg/200 mg, 5 mg/200 mg, 7.5 mg/200 mg, 10 mg/200 mg tablets | 2.5-10 mg every 4-6 hours as needed | 5 tablets per day [maximum hydrocodone dose (10mg/200 mg): 50 mg daily]** |
| Antitussive hydrocodone bitartrate/homatropine (Hydromet®, generics) | 5 mg/1.5 mg/5ml solution or 5 mg/1.5 mg tablet | 5 mg every 4-6 hours as needed | 30 mg daily |
| Antitussive hydrocodone polistirex/chlorpheniramine polistirex (TussiCaps®) | 10 mg/ 8 mg extended-release capsules | 1 capsule every 12 hours | 20 mg/16 mg every 24 hours |
| Antitussive hydrocodone polistirex/chlorpheniramine polistirex (Tussionex® Pennkinetic®, generics) | 10 mg/8 mg+/5 ml extended-release oral suspension | 10 mg/8 mg+ every 12 hours | 20 mg/16 mg+ daily |
Legend:
- *dosage limit based on maximum acetaminophen daily dose; varies by product
- **short-term use (less than 10 days) recommended
- +dosed as hydrocodone bitartrate and chlorpheniramine maleate