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June 10: VDP Formulary, CAD, MCO Search Realignment Now Active

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1.1.1. Renal Impairment

Patients prescribed galantamine with moderate renal impairment [creatinine clearance (CrCl) 9-59 ml/min] should have doses titrated cautiously; dosages should not exceed 16 mg daily. Galantamine is not recommended for use in patients with severe renal impairment (CrCl less than 9 ml/min)1,2,5-7 .

Patients with severe renal impairment (CrCl 5-29 ml/min) stabilized on memantine

5 mg twice daily immediate-release or 14 mg daily extended-release and donepezil

10 mg daily or donepezil 10 mg once daily without memantine may utilize memantine/donepezil combination therapy in doses not exceeding 14 mg/10 mg daily1,2,10.