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1.2. Pediatrics

Maximum recommended oral antidiabetic doses in pediatric patients are summarized in Table 12. Dosages exceeding these recommendations will be reviewed.

Table 12. Recommended Pediatric Oral Antidiabetic Agents- Monotherapy: Maximum Recommended Daily Dosages [1,4-7]
Drug NameDosage Form/StrengthTreatment IndicationsMaximum Recommended Dosage
metformin (generics)immediate-release tabletstype 2 diabetesgreater than 10 years of age:
2000 mg/day, in two divided doses
metformin (generics)500 mg/5 mL oral solutiontype 2 diabetesGreater than 10 years of age:
2000 mg/day, in two divided doses
Table 13.  Oral Antidiabetic Agents- Monotherapy: Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors Maximum Recommended Pediatric Daily Dosages [1,18-20]
Drug NameDosage Form/StrengthTherapeutic IndicationsMaximum Recommended Dosage
dapagliflozin (Farxiga, generics)5 mg, 10 mg tabletsType 2 diabetes!Greater than 10 years of age: 10 mg/day
empagliflozin (Jardiance)10 mg, 25 mg tabletstype 2 diabetes#Greater than 10 years of age: 25 mg/day
Table 14. Oral Antidiabetic  Agents- Combination Therapy: Maximum Recommended Pediatric Daily Dosages [1,33,36,37]
Drug NameDosage Form/StrengthTreatment IndicationsMaximum Recommended Dosage
dapagliflozin/metformin (Xigduo XR)2.5 mg/1000 mg, 5 mg/500 mg, 5 mg/1000 mg, 10 mg/500 mg, 10 mg/1000 mg tabletstype 2 diabetes!Greater than or equal to 10 years of age: 10 mg/2000 mg/day once daily
empagliflozin/metformin (Synjardy)5 mg/500 mg, 5 mg/1000 mg, 12.5 mg/500 mg, 12.5 mg/1000 mg tabletstype 2 diabetes#Greater than or equal to 10 years of age: 25 mg/2000 mg/day in two divided doses
empagliflozin/metformin (Synjardy XR)5 mg/1000 mg, 10 mg/1000 mg, 12.5 mg/1000 mg, 25 mg/1000 mg extended-release tabletstype 2 diabetes#Greater than or equal to 10 years of age: 25 mg/2000 mg/day once daily