1.2. Pediatrics

Maximum recommended oral antidiabetic doses in pediatric patients are summarized in Table 12. Dosages exceeding these recommendations will be reviewed.

Table 12. Recommended Pediatric Oral Antidiabetic Agents- Monotherapy: Maximum Recommended Daily Dosages [1,4-7]

Drug Name	Dosage Form/Strength	Treatment Indications	Maximum Recommended Dosage
metformin (generics)	immediate-release tablets	type 2 diabetes	greater than 10 years of age: 2000 mg/day, in two divided doses
metformin (generics)	500 mg/5 mL oral solution	type 2 diabetes	Greater than 10 years of age: 2000 mg/day, in two divided doses

Table 13.  Oral Antidiabetic Agents- Monotherapy: Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors Maximum Recommended Pediatric Daily Dosages [1,18-20]

Drug Name	Dosage Form/Strength	Therapeutic Indications	Maximum Recommended Dosage
dapagliflozin (Farxiga, generics)	5 mg, 10 mg tablets	Type 2 diabetes!	Greater than 10 years of age: 10 mg/day
empagliflozin (Jardiance)	10 mg, 25 mg tablets	type 2 diabetes#	Greater than 10 years of age: 25 mg/day

Table 14. Oral Antidiabetic  Agents- Combination Therapy: Maximum Recommended Pediatric Daily Dosages [1,33,36,37]

Drug Name	Dosage Form/Strength	Treatment Indications	Maximum Recommended Dosage
dapagliflozin/metformin (Xigduo XR)	2.5 mg/1000 mg, 5 mg/500 mg, 5 mg/1000 mg, 10 mg/500 mg, 10 mg/1000 mg tablets	type 2 diabetes!	Greater than or equal to 10 years of age: 10 mg/2000 mg/day once daily
empagliflozin/metformin (Synjardy)	5 mg/500 mg, 5 mg/1000 mg, 12.5 mg/500 mg, 12.5 mg/1000 mg tablets	type 2 diabetes#	Greater than or equal to 10 years of age: 25 mg/2000 mg/day in two divided doses
empagliflozin/metformin (Synjardy XR)	5 mg/1000 mg, 10 mg/1000 mg, 12.5 mg/1000 mg, 25 mg/1000 mg extended-release tablets	type 2 diabetes#	Greater than or equal to 10 years of age: 25 mg/2000 mg/day once daily