1.1. Adults

Analgesic hydrocodone dosages should be determined based on pain severity and patient response/ tolerance. In individuals with severe pain or those who have become tolerant to the analgesic effects of hydrocodone, it may be necessary to exceed the usual dosage. Reduced hydrocodone dosages are indicated in high-risk patients and the elderly. The maximum daily dosage for the acetaminophen/ hydrocodone combination is restricted by the maximum acetaminophen dose of 4 g daily to limit the risk of hepatic damage and severe hypersensitivity reactions associated with acetaminophen use ^2-4.

Hydrocodone exerts antitussive effects by directly acting on receptors in the cough center at dosages lower than those required for analgesia ^2,3,6,7.

Recommended adult hydrocodone dosages as monotherapy and combination therapy are summarized in Tables 1^2,3,8,9 and 2^2-7,10. Dosages exceeding these recommendations will be reviewed.