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1.2. Pediatrics

Safety and efficacy of enoxaparin for use in children younger than 18 years of age have not been established1,2. Dalteparin is FDA approved to treat VTE to reduce VTE recurrence in pediatric patients greater than or equal to 1 month of age1,3. Dalteparin pediatric dosages are summarized in Table 2. Dosages exceeding these recommendations will be reviewed.

Table 2. Pediatric LMWH Recommended Dosages1,2,4
Treatment IndicationDrug NameMaximum Recommended Dosage
Venous thromboembolism treatmentDalteparin
  • 4 weeks to less than 2 years:
    • 150 IU/kg twice daily as starting dose*
  • 2 years to less than 8 years:
    • 125 IU/kg twice daily as starting dose*
  • 8 years to less than 17 years:
    • 100 IU/kg twice daily as starting dose*

Legend

  • * = Adjust in increments of 25 IU/ kg to target and maintain anti-Xa level between 0.5 - 1 IU/ mL