1.1. Adults

Adult maximum daily NSAID dosages as monotherapy and combination therapy are summarized in Tables 1 and 2 and should not exceed these recommended maximum values.

Table 1. NSAID Maximum Recommended Daily Dosages for Adults: Monotherapy1-33, 37
Drug Name Dosage Form/Strength Treatment Indication Maximum Recommended Daily Dosage
aspirin extended-release (ER) (Durlaza®) 162.5 mg ER capsule Reduce risk of death and myocardial infarction (MI) in patients with coronary artery disease (CAD) such as patients with a history of MI, unstable angina pectoris, or chronic stable angina 162.5 mg once daily
    Reduce risk of death and recurrent stroke in patients with previous ischemic stroke or transient ischemic attack (TIA) 162.5 mg once daily
aspirin (generics) 81 mg chewable/EC tablets; 325 mg regular/EC tablets arterial thromboembolism prophylaxis 325 mg once daily
  81 mg chewable/enteric-coated (EC) tablets; 325 mg, 500 mg regular/EC tablets; 300 mg, 600 mg rectal suppositories fever, pain (mild to moderate including dysmenorrhea) 4000 mg/day in divided doses
  81 mg chewable/EC tablets; 325 mg regular/EC tablets myocardial infarction 325 mg x1 dose, chewed
  81 mg chewable/EC tablets myocardial infarction prevention 162 mg once daily
  325 mg, 500 mg, regular/EC tablets osteoarthritis 3000 mg/day in divided doses
  325 mg, 500 mg, regular/EC tablets osteoarthritis 3000 mg/day in divided doses
  325 mg, 500 mg, regular/EC tablets rheumatoid arthritis titrate to a plasma salicylate level between 150- 300 mcg/ mL
  81 mg chewable/EC tablets; 325 mg regular/EC tablets stroke prevention in patients with TIA or other stroke risk factors 325 mg once daily
choline magnesium trisalicylate 500 mg, 750 mg, 1000 mg tablets; 500 mg/5 mL solution fever, mild/ moderate pain 3000 mg/day in divided doses
    osteoarthritis, rheumatoid arthritis, or acute painful shoulder 3000 mg/ day in divided doses
diclofenac potassium (Cambia®) 50 mg oral powder for solution acute migraine attack with or without aura 50 mg (1 packet) as single dose
diclofenac potassium immediate-release (IR) (Lofena®, Cataflam®, generics) 25 mg (Lofena®, generics), 50 mg (Cataflam®, generics) IR tablets osteoarthritis 150 mg/day in divided doses
    pain (mild to moderate) 150 mg/day in divided doses
    primary dysmenorrhea 150 mg/day in divided doses
    rheumatoid arthritis 200 mg/day in divided doses
diclofenac sodium delayed- release (DR) (generics) 25 mg, 50 mg, 75 mg DR tablets ankylosing spondylitis 125 mg/day in divided doses
    osteoarthritis 150 mg/day in divided doses
    rheumatoid arthritis 200 mg/day in divided doses
diclofenac sodium extended-release (ER) (generics) 100 mg ER tablets osteoarthritis 100 mg once daily
    rheumatoid arthritis 200 mg/day in divided doses
diclofenac potassium (Zipsor®, generics) 25 mg capsule pain (mild to moderate) 100 mg/day in divided doses
diclofenac (Zorvolex®, generics) 18 mg, 35 mg (Zorvolex®, generics) capsules osteoarthritis 105 mg/day in divided doses
    pain (mild to moderate) 105 mg/day in divided doses
diflunisal 500 mg tablets osteoarthritis 1500 mg/day in divided doses
    pain (mild to moderate) 1500 mg/day in divided doses
    rheumatoid arthritis 1500 mg/day in divided doses
etodolac IR (generics) 200 mg, 300 mg IR capsule; 400 mg, 500 mg IR tablet acute pain 1200 mg/day in divided doses
    osteoarthritis 1200 mg/day in divided doses
    rheumatoid arthritis 1200 mg/day in divided doses
etodolac ER (generics) 400 mg, 500 mg, 600 mg ER tablets osteoarthritis 1200 mg once daily
    rheumatoid arthritis 1200 mg once daily
fenoprofen capsules (Nalfon®, generics); tablets (Nalfon®, generics) 200 mg, 400 mg capsules; 600 mg tablets osteoarthritis 3200 mg/day in divided doses
    pain (mild to moderate) 3200 mg/ day in divided doses
    rheumatoid arthritis 3200 mg/day in divided doses
flurbiprofen (generics) 50 mg, 100 mg tablets osteoarthritis 300 mg/day in divided doses
    rheumatoid arthritis 300 mg/day in divided doses
ibuprofen (Advil®, Motrin®, generics) 100 mg chewable tablets; 200 mg, 400 mg, 600 mg, 800 mg tablets; 200 mg capsule; 100 mg/5 mL suspension dysmenorrhea 3200 mg/day in divided doses
    fever 3200 mg/day in divided doses
    headache 3200 mg/day in divided doses
    migraine 3200 mg/day in divided doses
    osteoarthritis 3200 mg/day in divided doses
    pain (mild to moderate) 3200 mg/day in divided doses
    rheumatoid arthritis 3200 mg/day in divided doses
indomethacin IR (generics) 25 mg, 50 mg capsules; 25 mg/5 mL suspension acute bursitis or tendinitis 200 mg/day in divided doses
    acute gouty arthritis 200 mg/day in divided doses
    ankylosing spondylitis 200 mg/day in divided doses
    osteoarthritis 200 mg/day in divided doses
    rheumatoid arthritis 200 mg/day in divided doses
indomethacin ER (generics) 75 mg ER capsules acute bursitis or tendinitis 150 mg/day in divided doses
    ankylosing spondylitis 150 mg/day in divided doses
    osteoarthritis 150 mg/day in divided doses
    rheumatoid arthritis 150 mg/day in divided doses
indomethacin (Tivorbex®, generics) 20 mg capsules acute pain (mild to moderate) 120 mg/day in divided doses
indomethacin rectal (Indocin®) 50 mg rectal suppository acute bursitis or tendinitis 150 mg/day in divided doses; no more than 100 mg per dose
    acute gouty arthritis 150 mg/day in divided doses; no more than 100 mg per dose
    ankylosing spondylitis 200 mg/day in divided doses; no more than 100 mg per dose
    osteoarthritis 200 mg/day in divided doses; no more than 100 mg per dose
    rheumatoid arthritis 200 mg/day in divided doses; no more than 100 mg per dose
ketoprofen IR (generics) 25 mg, 50 mg, 75 mg IR capsules osteoarthritis 300 mg/day in divided doses
    pain (mild/moderate, including acute dysmenorrhea) 300 mg/day in divided doses
    rheumatoid arthritis 300 mg/day in divided doses
ketoprofen ER (generics) 200 mg ER capsule osteoarthritis 200 mg once daily
    rheumatoid arthritis 200 mg once daily
ketorolac (generics) 10mg tablets acute pain (moderately severe) following IV or IM treatment 40 mg/day in divided doses
magnesium salicylate (Doans®, generics) 580 mg extended-release caplets pain (mild/moderate) 4640 mg/day (8 caplets) in divided doses
meclofenamate (generics) 50 mg, 100 mg capsules acute bursitis or tendinitis 400 mg/day in divided doses
    acute gouty arthritis 400 mg/day in divided doses
    ankylosing spondylitis 400 mg/day in divided doses
    dysmenorrhea and idiopathic heavy menstrual blood loss 300 mg/day in divided doses
    osteoarthritis 400 mg/day in divided doses
    pain (mild/ moderate) 400 mg/day in divided doses
    rheumatoid arthritis 400 mg/day in divided doses
mefenamic acid (generics) 250 mg capsules pain (mild/ moderate including dysmenorrhea) 1250 mg in divided doses on day 1; 1000 mg/day in divided doses on days 2-7
meloxicam (Mobic®, generics) 7.5 mg, 15 mg tablets, 7.5 mg/ 5 mL suspension osteoarthritis 15 mg/day once daily
    rheumatoid arthritis 15 mg/day once daily
meloxicam (Vivlodex®, generics) 5 mg, 10 mg capsules osteoarthritis 10 mg/day once daily
nabumetone (generics) 500 mg, 750 mg tablets osteoarthritis 2000 mg/day in single or divided doses
    rheumatoid arthritis 2000 mg/day in single or divided doses
naproxen IR (Aleve®, Naprosyn®,  generics) 220 mg IR capsule; 220 mg, 250 mg, 275 mg, 375 mg, 500 mg IR tablets; 125 mg/5 mL IR suspension acute gout 1500 mg/day in divided doses
    ankylosing spondylitis 1500 mg/day in divided doses
    bursitis/tendinitis 1500 mg/day in divided doses
    osteoarthritis 1500 mg/day in divided doses
    pain (mild/moderate including dysmenorrhea) 1500 mg/day in divided doses
    rheumatoid arthritis 1500 mg/day in divided doses
naproxen sodium (Anaprox DS®, generics) 220 mg, 275 mg, 550 mg IR tablets acute gout 1650 mg/day in divided doses
    ankylosing spondylitis 1650 mg/day in divided doses
    bursitis/tendinitis 1650 mg/day in divided doses
    osteoarthritis 1650 mg/day in divided doses
    pain (mild/moderate including dysmenorrhea) 1650 mg/day in divided doses
    rheumatoid arthritis 1650 mg/day in divided doses
naproxen DR (EC-Naprosyn®, generics) 375 mg, 500 mg DR tablets ankylosing spondylitis 1500 mg/day in divided doses
    osteoarthritis 1500 mg/day in divided doses
    rheumatoid arthritis 1500 mg/day in divided doses
naproxen ER (Naprelan®, generics 375 mg, 500 mg, 750 mg ER tablets acute gout 1500 mg/day in divided doses
    ankylosing spondylitis 1500 mg/day in divided doses
    bursitis/tendinitis 1500 mg/day in divided doses
    osteoarthritis 1500 mg/day in divided doses
    pain (mild/moderate including dysmenorrhea) 1500 mg/day in divided doses
    rheumatoid arthritis 1500 mg/day in divided doses
oxaprozin (Daypro®, generics) 600 mg tablets osteoarthritis 1800 mg/day (not to exceed 26 mg/kg/day) in divided doses
    rheumatoid arthritis 1800 mg/day (not to exceed 26 mg/kg/day) in divided doses
piroxicam (Feldene®, generics) 10 mg, 20 mg capsules osteoarthritis 20 mg once daily
    rheumatoid arthritis 20 mg once daily
salsalate (Disalcid®, generics) 500 mg, 750 mg tablets osteoarthritis 3000 mg/day in divided doses
    rheumatoid arthritis 3000 mg/day in divided doses
sulindac (generics) 150 mg, 200 mg tablets acute gouty arthritis 400 mg/day in divided doses
    ankylosing spondylitis 400 mg/day in divided doses
    bursitis/tendinitis of shoulder 400 mg/day in divided doses
    osteoarthritis 400 mg/day in divided doses
    rheumatoid arthritis 400 mg/day in divided doses
Table 2. NSAID Maximum Recommended Daily Dosages for Adults: Non-Opioid Combination Therapy1,2,34-36
Drug Name Dosage Form/Strength Treatment Indication Maximum Recommended Daily Dosage
acetaminophen/ aspirin/caffeine (Excedrin® Migraine, generics) 250 mg/250 mg/65 mg tablets migraine headache 2 tablets/24 hours
    pain, including headache 8 tablets/24 hours in divided doses
acetaminophen/aspirin/caffeine (Goody’s®) 260 mg/520 mg/32.5 mg powders pain, including headache 4 powders/24 hours in divided doses
aspirin/butalbital/caffeine (Fiorinal®, generics) 325 mg/50 mg/40 mg capsules, tablets tension or muscle contraction headache 6 capsules/24 hours in divided doses (1 or 2 every 4 hours)
diclofenac/misoprostol  (Arthrotec®, generics) 50 mg/200 mcg, 75 mg/200 mcg delayed-release tablet osteoarthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers 150 mg/600 mcg/day in divided doses
    rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers 200 mg/800 mcg/day in divided doses
ibuprofen/famotidine (Duexis®, generic) 800 mg/26.6 mg tablet pain relief in osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers 2400 mg/79.8 mg/day in divided doses
    pain relief in rheumatoid arthritis and to decrease the risk of developing upper gastrointestinal ulcers 2400 mg/79.8 mg/day in divided doses
naproxen/esomeprazole (Vimovo®, generic) 375 mg/20 mg, 500 mg/20 mg delayed-release tablet ankylosing spondylitis in patients at risk of developing NSAID-associated ulcers 1000 mg/40 mg/day in divided doses
    osteoarthritis in patients at risk of developing NSAID-associated ulcers 1000 mg/40 mg/day in divided doses
    rheumatoid arthritis in patients at risk of developing NSAID-associated ulcers 1000 mg/40 mg/day in divided doses