3. Duplicative Therapy

Zileuton (Zyflo®), a 5-lipoxygenase inhibitor, inhibits formation of cysteinyl leukotrienes. Concurrent administration of LTRAs with zileuton does not provide additional clinical benefit and may increase risk of developing adverse events. Concurrent administration of LTRAs with zileuton is not recommended and will be reviewed.

Adjunctive administration of montelukast and zafirlukast does not provide additional clinical benefit and may result in additive adverse effects. Combined administration of montelukast and zafirlukast is not recommended and will be reviewed.