1.1. Adults

Adult dosage recommendations for LTRAs are summarized in Table 1. Patient profiles containing dosages not conforming to these recommendations will be reviewed.

Table 1. LTRA Adult Dosage Recommendations1-4
Drug Name Dosage Form/Strength Treatment Indication Maximum Recommended Dosage
montelukast (Singulair®, generics) 10 mg tablets, 4 mg, 5 mg chewable tablets, 4 mg oral granule packets asthma 10 mg once daily in the evening 
    prophylaxis, exercise-induced bronchoconstriction 10 mg as a single dose, at least 2 hours before exercise; dose should not be repeated within 24 hours of previous dose
    perennial and/or seasonal allergic rhinitis 10 mg daily
zafirlukast (Accolate®, generics) 10 mg, 20 mg tablets asthma 20 mg twice daily